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“Patient’s Cells Deployed to Attack Aggressive Cancer”:Article Summary

“Patient’s Cells Deployed to Attack Aggressive Cancer”:Article Summary

The current paper examines the article “Patient’s Cells Deployed to Attack Aggressive Cancer” by Denise Grady (2014). The author demonstrates that doctors have made a significant step towards increasing people’s immune potential for fighting cancer. Modern research in this field is largely based on the case of a 43-year-old woman that had a very difficult form of cancer but was able to develop her immune system with the help of the immune cells grown in the laboratory. Although her tumors are not gone, they have been substantially shrinking. Thus, doctors hope that this positive experience may be generalized into a new complex system for dealing with cancer.

One case cannot guarantee the effectiveness of this new approach. However, it may be applied to typical tumors that correspond to the largest fraction of deaths in the US. Similar techniques that are based on the use of immune cells also demonstrate positive results for patients with melanoma, blood cancer, etc. Thus, indirect facts support the hypothesis about the effectiveness of the new approach. This treatment is known as adoptive cell therapy, and it is already recognized as one of the most promising and innovative approaches in this sphere. However, specialists stress that the eport is based on only one patient, and further research is needed in order to clarify the statistical significance of the obtained results.

Dr. Carl June said that this therapy demonstrated that immune cells could counter-balance the influence of tumors which usually led to lethal cases. Some immune cells are also considered as a potential tool for minimizing the negative consequences of bile-duct cancer. In order to expand the applicability of this technique to various patients, it should be modified, and its complexity should be reduced. A number of specialists work in this direction.

The success of Dr. Rosenberg’s team may be attributed to the discovery of the unique T cells that may attack the cancer mutation. The team was able to receive more than 100 billion of such cells, the majority of which were specific. The patient’s tumors began shrinking, and her overall physical state improved greatly. The determined T cells may help several other patients with similar problems. However, further elaborations are needed.

Thus, this article directly relates to the issues discussed in Chapters 13-15 as it deals with modern approaches to attacking cancer cells. This article affected my understanding of the problem ssignificantly as I understood that adoptive cell therapy could be considered as the most innovative and potentially the most effective method of dealing with the most difficult type of cancer. I think that the project of Dr. Rosenberg’s team is unique because they have developed a hypothesis about the positive effect of T cells, have found such cells, and have attacked tumors. As a result, the immune therapy has helped the patient to improve her health substantially. Although tumors are not completely gone, the positive tendency clearly demonstrates the unprecedented effects of the therapy. I suggest that the experience of Dr. Rosenberg’s team may serve as a model for future research in this area.

Moreover, I have known that this approach may be potentially helpful for patients with different types of cancer (blood cancer, melanoma, etc.); it makes it even more valuable and influential for modern researchers and practitioners. I believe that the effectiveness of this approach may be partially explained with the fact that the internal forces and patient’s immune potential also contribute to attacking cancer cells. It means that adoptive cell therapy treats a patient as an active participant in the treatment process rather than a passive object of the external influence.



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